Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments

Biodegradable Polymeric Nanoparticles-Based Vaccine Adjuvants for Lymph Nodes Targeting

Vaccines have successfully eradicated a large number of diseases. However, some infectious diseases (such as HIV, Chlamydia trachomatis or Bacillus anthracis) keep spreading since there is no vaccine to prevent them. One way to overcome this issue is the development of new adjuvant formulations which are able to induce the appropriate immune response without sacrificing safety. Lymph nodes are ...

Memantine Loaded Biodegradable Polymeric Nanoparticles for Glaucoma Treatment

Extended Abstract Recent studies have shown that treatment with Memantine (MEM) protected retinal ganglion cells in monkey models of glaucoma, reducing ganglion cell loss during treatment with this drug (Hare et al, 2009). An important goal is the development of a safe and effective formulation for delivery of Memantine to the eye posterior segment. In this way, biodegradable polyesters such as...

Nanoparticles of biodegradable polymers for cancer treatment.

Smart Polymeric Nanoparticles for Cancer Gene Delivery

The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral...

Treatment of Breast Cancer with Silver Antitumor Drugs Encapsulated In Biodegradable Polymeric Nanoparticles

Several silver N-heterocyclic carbene complexes have been synthesized and tested for their anticancer activity. In vitro studies have shown these complexes to be active against ovarian, breast, melanoma, colon, renal, bladder, and prostate human cancer cell lines. An in vivo study on a silver carbene complex using an ovarian cancer (OVCAR-3) xenograft model in athymic nude mice has produced enc...